---

~1996年 (金倉教授論文)

96. Nishiura, T., Karasuno, T., Yoshida, H., Nakao, H., Ogawa, M., Horikawa, Y., Yoshimura, M., Okajima, Y., Kanakura, Y., Kanayama, Y., and Matsuzawa, Y. Functional role of cation-independent mannose 6-phosphate/insulin-like growth factor II receptor in cell adhesion and proliferation of a human myeloma cell line OPM-2. Blood, 88:3546-3554, 1996.

95. Matsumura, I., Kanakura, Y., Kato, T., Ikeda, H., Horikawa, Y., Ishikawa, J., Kitayama, H., Nishiura, T., Tomiyama, Y., Miyazaki, H., and Matsuzawa, Y. The biological properties of human recombinant thrombopoietin in the proliferation and megakaryocytic differentiation of acute myeloblastic leukemia cells. Blood., 88:3074-3082, 1996.

94. Shiraga, M., Tomiyama, Y., Honda, S., Kashiwagi, H., Kosugi, S., Handa, M., Ikeda, Y., Kanakura, Y., Kurata, Y., and Matsuzawa, Y. Affinity modulation of the platelet integrin aIIbb3 chymotrypsin: a possible role for Na+/Ca2+ exchanger. Blood, 88:2594-2602, 1996.

93. Kashiwagi, H., Tomiyama, Y., Nozaki, S., Honda, S., Kosugi, S., Shiraga, M., Nakagawa, T., Nagao, N., Kanakura, Y., Kurata, Y., and Matsuzawa, Y. A single nucleotide insertion in codon 317 of the CD36 gene leading to CD36 deficiency. Arterioscler. Thromb. Vasc. Biol. , 16:1026-1032, 1996.

92. Tsujimura, T., Morii, E., Nozaki, M., Hashimoto, K., Moriyama, Y., Takebayashi, K., Kondo, T., Kanakura, Y., and Kitamura, Y. Involvement of transcription factor encoded by the mi locus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of mice. Blood, 88:1225-1233, 1996.

91. Kitayama, H., Tsujimura, T., Matsumura, I., Oritani, K., Ikeda, H., Ishikawa, J., Okabe, M., Suzuki, M., Yamamura, K-I., Matsuzawa, Y., Kitamura, Y., and Kanakura, Y. Neoplastic transformation of normal hematopoietic cells by constitutively activating mutation of c-kit receptor tyrosine kinase. Blood, 88:995-1004, 1996.

90. Kosugi, S., Kurata, Y., Tomiyama, Y., Tahara, T., Kato, T., Tadokoro, S., Shiraga, M., Honda, S., Kanakura, Y., and Matsuzawa, Y. Circulating thrombopoietin level in chronic immune thrombocytopenic purpura. Br. J. Haematol., 93:704-706, 1996.

89. Matsumura, I., Ikeda. H., and Kanakura, Y. Effect of thrombopoietin on the growth of acute myeloblastic leukemia cells. Leukemia Lymphoma, 23:533-538, 1996.

88. Moriyama, Y., Tsujimura, T., Hashimoto, K., Kitayama, H., Morimoto, M., Matsuzawa, Y., Kitamura, Y., and Kanakura, Y. Role of aspartic acid 814 in the function and expression of c-kit receptor tyrosine kinase. J. Biol. Chem., 271:3347-3350, 1996.

87. Yoshimura, M., Ihara, Y., Ohnishi, A., Ijuhin, N., Nishiura, T., Kanakura, Y., Matsuzawa, Y., and Taniguchi, N. Bisecting N-acetylglucosamine on K562 cells is suppressive to natural killer cytotoxicity and promote spleen colonization. Cancer Res., 56:412-418, 1996.

86. Kosugi, S., Tomiyama, Y., Shiraga, M., Kashiwagi, H., Mizutani, H., Kanakura, Y., Kurata, Y., and Matsuzawa, Y. Platelet-associated anti-glycoprotein (GP) IIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura mainly recognize cation-dependent conformation: comparison with the epitopes of serum autoantibodies. Thromb. Haemost., 75:339-345, 1996.

85. Kanakura, Y., Ikeda, H., Tsujimura, T., and Kitayama, H. The c-kit receptor tyrosine kinase: its role in hematological malignancies. Cancer J., 9:79-82, 1996.

84. Terui, Y., Furukawa, Y., Sakai, T., Kikuchi, J., Sugahara, H., Kanakura, Y., Kitagawa, S., and Miura, Y. Up-regulation of VLA-5 expression during monocytic differentiation and its role in negative regulation of the survival of peripheral blood monocytes. J. Immunol., 156:1981-1988, 1996.

83. Hashimoto, K., Tsujimura, T., Moriyama, Y., Yamatodani, A., Kimura, M., Tohya, K., Morimoto, M., Kitayama, H., Kanakura, Y., and Kitamura, Y. Transforming and differentiation-inducing potentials of c-kit receptor tyrosine kinase with activting mutations in the IC-2 murine interleukin-3-dependent mast cell line. Am. J. Pathol., 148:189-200, 1996.

82. Tsujimura, T., Morimoto, M., Hashimoto, K., Moriyama, Y., Kitayama, H., Matsuzawa, Y., Kitamura, Y., and Kanakura, Y. Constitutive activation of c-kit in FMA murine mastocytoma cells caused by deletion of seven amino acids at the juxtamembrane domain. Blood, 87:273-283, 1996.

81. Matsumura, I., Kanakura, Y., Ikeda, H., Ishikawa, J., Yoshida, H., Horikawa, Y., Nishiura, T., Tahara, T., Kato, T., Miyazaki, H., and Matsuzawa, Y. Coexpression of thrombopoietin and c-mpl genes in human acute myeloblastic leukemia cells. Leukemia, 10:91-94, 1996.

80. Mizutani, H., Kurata, Y., Kosugi, S., Shiraga, M., Kashiwagi, H., Tomiyama, Y., Kanakura, Y., Good, R. A., and Matsuzawa, Y. Monoclonal anticardiolipin autoantibodies established from the (New Zealand White X BXSB)F1 mouse model of antiphospholipid syndrome cross-react with oxidized low-density lipoprotein. Arthr. Rheumat., 38:1382-1388, 1995.

79. Kitamura, Y., Tsujimura, T., Jippo, T., Kasugai, T., and Kanakura, Y. Regulation of depvelopment, survival and neoplastic growth of mast cells through c-kit receptor. Int. Arch. Allergy Immunol., 107:54-56, 1995.

78. Ito, A., Hirota, S., Mizuni, H., Kawasaki, Y., Takemura, T., Nishiura, T., Kanakura, Y., Katayama, Y., Nomura, S., and Kitamura, Y. Expression of vascular permeability factor (VPF/VEGF) messenger RNA by plasma cells: possible involvement in the edema in chronic inflammation. Pathol. Int., 45:715-720, 1995.

77. Kashiwagi, H., Tomiyama, Y., Kosugi, S., Shiraga, M., Lipsky, R. H., Nagao, N., Kanakura, Y., Kurata, Y., and Matsuzawa, Y. Familial studies of type II CD36 deficient subjectes: linkage of a CD36 allele to a platelet specific mRNA expression defect(s) causing type II CD36 deficiency. Thromb. Haemost., 74:758-763, 1995.

76. Matsumura, I., Kanakura, Y., Kato, T., Ikeda, H., Ishikawa, J., Horikawa, Y.,Hashimoto, K., Moriyama, Y., Tsujimura, T., Nishiura, T., Miyazaki, H., and Matsuzawa, Y. Growth response of acute myeloblastic leukemia cells to recombinant human thrombopoietin. Blood, 86:703-709, 1995.

75. Hashimoto, K., Kanakura, Y., Yagura, H., Mitsui, H., Horikawa, Y., Ogawa, A., Nishiura, T., Kanayama, Y., and Matsuzawa, Y. Early trilineage recovery by granulocyte colony-stimulating factor in a patient with aplastic anemia. Acta Haematol., 93:110-112, 1995.

74. Tsujimura, T., Furitsu, T., Morimoto, M., Kanayama, Y., Nomura, S., Matsuzawa, Y., Kitamura, Y., and Kanakura, Y. Substitution of an aspartic acid results in constitutive activation of c-kit receptor tyrosine kinase in a rat tumor mast cell line RBL-2H3. Int. Arch. Allergy Immunol., 106:377-385, 1995.

73. Kitamura, Y., Tsujimura, T., Jippo, T., Kasugai, T., and Kanakura, Y. Development of mast cells and basophils: role of c-kit receptor tyrosine kinase for development, survival and neoplastic transformation of mast cells. In Biological and Molecular Aspect of Mast Cell and Basophil Differentiation and Function, (eds, Kitamura, Y., Yamamoto, S., Galli, S. J., and Greaves, M. W.), Raven Press, New York, NY, pp 91-103, 1995.

72. Kitayama, H., Kanakura, Y., Furitsu, T., Tsujimura, T., Oritani, K., Ikeda, H., Sugahara, H., Mitsui, H., Kanayama, Y., Kitamura, Y., and Matsuzawa, Y. Constitutively activating mutations of the c-kit proto-oncogene confer factor-independence and tumorigenisity of factor-dependent hematopoietic cell lines. Blood, 85:790-798, 1995.

71. Ishihara, K., Yoshimura, M., Nakao, H., Kanakura, Y., Kanayama, Y., and Matsuzawa, Y. T cell abnormalities in mixed connective tissue disease occurring in Klinefelter's syndrome: a case report. Int. Medicine, 33:714-717, 1994.

70. Okuda, K., Matulonis, U., Salgia, R., Kanakura, Y., Druker, B., and Griffin, J.D. Factor independence of human myeloid leukemia cell lines is associated with increased phosphorylation of the proto-oncogene Raf-1. Exp. Hematol., 22:1111-1117, 1994.

69. Sugahara, H., Kanakura, Y., Furitsu, T., Ishihara, K., Oritani, K., Ikeda, H., Kitayama, H., Ishikawa, J., Hashimoto, K., Kanayama, Y., and Matsuzawa, Y. Induction of programmed cell death in human hematopoietic cell lines by fibronectin via its interaction with very late antigen 5. J. Exp. Med., 179:1757-1766, 1994.

68. Tsujimura, T., Furitsu, T., Morimoto, M., Isozaki, K., Nomura, S., Matsuzawa, Y., Kitamura, Y., and Kanakura, Y. Ligand-independent activation of a c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation. Blood, 83:2619-2626, 1994.

67. Tei, H., Kasugai, T., Tsujimura, T., Adachi, S., Furitsu, T., Tohya, K., Kimura, M., Zsebo, K. M., Newlands, G. F. J., Miller H. R. P., Kanakura, Y., and Kitamura, Y. Characterization of cultured mast cells derived from Ws/Ws mast cell-deficient rats with a small deletion at tyrosine kinase domain of c-kit. Blood, 83:916-925, 1994.

66. Kitamura, Y., Tsujimura, T., Nomura, S., and Kanakura, Y. Physiological roles of c-KIT receptor tyrosine kinase: an analysis using mutant animals. In Gann Monograph Cancer Res. Growth Factors in Cell Growth Morphogenesis and Transformation., (eds, Nakamura, T., Matsumoto, K.), Japan Scientific Societies Press, Tokyo, Vol 42, pp 51-61, 1994.

65. Kanakura, Y., Furitsu, T., Tsujimura, T., Butterfield, J. H., Ashman, L. K., Ikeda, H., Kitayama, H., Kanayama, Y., Matsuzawa, Y., and Kitamura, Y. Activating mutations of the c-kit proto-oncogene in a human mast cell leukemia cell line. Leukemia, 8 (Suppl. 1):S18-S22, 1994.

64. Ebi, Y., Kanakura, Y., Jippo-Kanemoto, T., Tsujimura, T., Furitsu, T., Ikeda, H., Kanayama, Y., Matsuzawa, Y., Tarui, S., and Kitamura, Y. Effect of mi (microphtalmia) locus on expression of c-kit and proteases in cultured mast cells of mi/mi genotype: low c-kit expression as a causal role of mast cell defect in mi/mi mice. In Mol. Biol. Hematopoiesis (eds, Abraham, N. G., Shadduck, R. K., Levine, A. S., Takaku, F.), Scientific, Medical & Technical Publicaions, Paris, France, Vol. 3, pp 107-115, 1994.

63. Koshimizu, U., Tsujimura, T., Isozaki, K., Nomura, S., Furitsu, T., Kanakura, Y., Kitamura, Y., and Nishimune, Y. Wn mutation of c-kit receptor affects its post-translational processing and extracellular expression. Oncogene, 9:157-162, 1994.

62. Ikeda, H., Kanakura, Y., Furitsu, T., Kitayama, H., Sugahara, H., Nishiura, T., Karasuno, T., Tomiyama, Y., Yamatodani, A., Kanayama, Y., and Matsuzawa, Y. Changes in phenotype and proliferative potential of acute myeloblastic leukemia cells in long-term culture with the c-kit ligand, stem cell factor. Exp. Hematol., 21:1686-1694, 1993.

61. Morimoto, M., Kasugai, T., Tei, H., Jippo-Kanemoto, T., Kanakura, Y., and Kitamura, Y. Age-dependent amelioration of hypoplastic anemia in Ws/Ws rats with a small deletion at the kinase domain of c-kit. Blood, 82:3315-3320, 1993.

60. Hirata, T., Morii, E., Morimoto, M., Kasugai, T., Tsujimura, T., Hirota, S., Kanakura, Y., Nomura, S., and Kitamura, Y. Stem cell factor induces outgrowth of c-kit-positive neurites and supports the survival of c-kit-positive neurons in dorsal root ganglia of mouse embryos. Development, 119:49-56, 1993.

59. Furitsu, T., Tsujimura, T., Tohno, T., Ikeda, H., Kitayama, H., Koshimizu, U., Sugahara, H., Butterfield, J. H., Ashman, L. K., Kanayama, Y., Matsuzawa, Y., Kitamura, Y., and Kanakura, Y. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J. Clin. Invest., 92:1736-1744, 1993.

58. Kanakura, Y., Ikeda, H., Kitayama, H., Sugahara, H., and Furitsu, T. Expression, function and activation of proto-oncogene c-kit product in human leukemia cells. Leukemia Lymphoma, 10:35-41, 1993.

57. Tsujimura, T., Koshimizu, U., Katoh, H., Isozaki, K., Kanakura, Y., Tono, T., Adachi, S., Kasugai, T., Tei, H., Nishimune, Y., Nomura, S., and Kitamura, Y. Mast cell number in the skin of heterozygotes reflects the molecular nature of c-kit mutation. Blood, 81:2530-2538, 1993.

56. Kanakura, Y., Sugahara, H., Mitsui, H., Ikeda, H., Furitsu, T., Yagura, H., Kitayama, H., Kanayama, Y., and Matsuzawa, Y. Functional expression of interleukin-2 receptor in a human factor-dependent megakaryoblastic leukemia cell line: Evidence that granulocyte-macrophage colony-stimulating factor inhibits binding of interleukin-2 binding to its receptor. Cancer Res., 53:675-680, 1993.

55. Kitayama, H., Kanakura, Y., Furitsu, T., Ikeda, H., Hirota, S., Sugahara, H., Yamatodani, A., Kanayama, Y., Kitamura, Y., and Matsuzawa, Y. Regulation of basophilic and erythroid differentiation of a human chronic myelogenous leukemia cell line, KU812F, by interleukin-3 and stem cell factor. Int. J. Oncol., 2:213-219, 1993.

54. Ebi, Y., Kanakura, Y., Jippo-Kanemoto, T., Tsujimura, T., Furitsu, T., Ikeda, H., Adachi, S., Kasugai, T., Nomura, S., Kanayama, Y., Yamatodani, A., Nishikawa, S-I., Matsuzawa, Y., and Kitamura, Y. Low c-kit expression of cultured mast cells of mi/mi genotype may be involved in their defective responses to fibroblasts that express the ligand for c-kit. Blood, 80:1454-1462, 1992.

53. Petrons, W. P., Rabinowitz, J., Stuart, A. R., Gilbert, C. J., Kanakura, Y., Griffin, J.D., and Peters, W. P. Disposition of recombinant human granulocyte-macrophage colony-stimulating factor in patients receiving high-dose chemotherapy and autologous bone marrow support. Blood, 80:1135-1140, 1992.

52. Okuda, K., Sanghera, J. S., Pelech, S. L., Kanakura, Y., Hallek, M., Griffin, J. D., and Druker, B. J. Granulocyte-macrophage colony-stimulating factor, Interleukin-3, and steel factor induce tyrosyl phosphorylation of p42 and p44 MAP kinase. Blood, 79:2880-2887, 1992.

51. Tamaki, T., Kanakura, Y., Kuriu, A., Ikeda, H., Mitsui, H., Yagura, H., Matsumura, I., Druker, B., Griffin, J. D., Kanayama, Y., and Yonezawa, T. Surface immunoglobulin-mediated signal transduction involves rapid phosphorylation and activation of the proto-oncogene Raf-1 in human B cells. Cancer Res., 52:566-570, 1992.

50. Ikeda, H., Kanakura, Y., Tamaki, T., Kuriu, A., Kitayama, H., Ishikawa, J., Kanayama, Y., Yonezawa, T., Tarui, S., and Griffin, J. D. Expression and functional role of the proto-oncogene c-kit in acute myeloblastic leukemia cells. Blood, 78:2962-2968, 1991.

49. Kuriu, A., Ikeda, H., Kanakura, Y., Griffin, J. D., Druker, B., Yagura, H., Kitayama, H., Ishikawa, J., Nishiura, T., Kanayama, Y., Yonezawa, T., and Tarui, S. Proliferation of human myeloid leukemia cell line associated with the tyrosine-phosphorylation and activation of the proto-oncogene c-kit product. Blood, 78:2834-2840, 1991.

48. Okuda, K., Druker, B., Kanakura, Y., Koenigsman, M., and Griffin, J. D. Internalization of the granulocyte-macrophage colony-stimulating factor receptor is not required for induction of protein tyrosine phosphorylation in human myeloid cells. Blood, 78:1928-1935, 1991.

47. Kanakura, Y., Cannistra, S. A., Brown, C. B., Nakamura, M., Seelig, G. F., Prosise, W. W., Hawkins, J. C., Kaushansky, K., and Griffin, J. D. Identification of functionally distinct domains of human granulocyte-macrophage colony stimulating factor using monoclonal antibodies. Blood, 77:1033-1043, 1991.

46. Mitsui, H., Yagura, H., Tamaki, T., Ikeda, H., Matsumura, I., Kanakura, Y., Yonezawa, T., and Tarui, S. High-affinity interleukin 2 receptors on B-cell chronic lymphocytic leukemia cells are induced by phorbol myristate acetate but not by calcium ionophore. Immunol. Lett., 27:105-112, 1991.

45. Kanakura, Y., Druker, B., DiCarlo, J., Cannistra, S. A., and Griffin, J. D. Phorbol 12-myristate 13-acetate inhibits granulocyte-macrophage colony-stimulating factor-induced protein tyrosine phosphorylation in a human factor-dependent cell line. J. Biol. Chem., 266:490-495, 1991.

44. Cannistra, S. A., DiCarlo, J., Groshek, P., Kanakura, Y., Berg, D., Mayer, R. J., and Griffin, J. D. Simultaneous administration of granulocyte-macrophage colony stimulating factor and cytosine arabinoside for treatment of relapsed acute myeloid leukemia. Leukemia, 5:230-238, 1991.

43. Kanakura, Y., Druker, B., Wood, K. W., Mamon, H. J., Okuda, K., Roberts, T. M., and Griffin, J. D. Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor-dependent myeloid cell line. Blood, 77:243-248, 1991.

42. Furukawa, Y., Piwnica-Worms, H., Ernst, T. J., Kanakura, Y., and Griffin, J. D. cdc2 gene expression at the G1 to S transition in human T lymphocytes. Science, 250:805-808, 1990.

41. Griffin, J. D., Spertini, O., Ernst, T. J., Belvin, M. P., Levine, H. B., Kanakura, Y, and Tedder, T. F. Granulocyte-macrophage colony-stimulating factor and other cytokines regulate surface expression of the leukocyte adhesion molecule-1 on human neutrophils, monocytes, and their precursors. J. Immunol., 145:576-584, 1990.

40. Kanakura, Y., Druker, B., Cannistra, S. A., Furukawa, Y., Torimoto, Y., and Griffin, J. D. Signal transduction of the human granulocyte-macrophage colony-stimulating factor and interleukin 3 receptors involves tyrosine phosphorylation of a common set of cytoplasmic proteins. Blood, 76:706-715, 1990.

39. Furukawa, Y., DeCaprio, J. A., Freedman, A., Kanakura, Y., Nakamura, M., Ernst, T. J., Livingston, D. M., and Griffin, J. D. Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells. Proc. Natl. Acad. Sci., U.S.A., 87:2770-2774, 1990.

38. Griffin, J. D., Demetri, G. D., Kanakura, Y., Cannistra, S. A., and Ernst, T. J. Cellular interactions regulating the production of colony stimulating factors. Hematopoietic Growth Factors in Transfusion Medicine. In Prog. Clin. Biol. Res., (eds, Spivak, J., Drohan, W., Dooley, W.), Wiley-Liss, New York, NY, Vol. 338, pp129-142, 1990.

37. Nakamura, M., Kanakura, Y., Furukawa, Y., Ernst, T. J., and Griffin, J. D. Demonstration of interleukin 1b transcripts in acute myeloblastic leukemia cells by in situ hybridization. Leukemia, 4:466-470, 1990.

36. Fukuzumi, T., Waki, N., Kanakura, Y., Nagoshi, J., Hirota, S., Yoshikawa, K., and Kitamura, Y. Differences in irradiation susceptivity and turnover between mucosal and connective tissue-type mast cells. Exp. Hematol., 18:843-847, 1990.

35. Griffin, J. D., Cannistra, S. A., Sullivan, R., Demetri, G. D., Ernst, T. J., and Kanakura, Y. The biology of GM-CSF: regulation of production and interaction with its receptor. Int. J. Cell Clon., 8:35-45 (Suppl 1), 1990.

34. Waki, N., Kitamura, Y., Kanakura, Y., Asai, H., and Nakano, T. Intraperitoneal injected cultured mast cells suppress recruitment and differentiation of bone marrow-derived mast cell precursors in the peritoneal cavity of W/Wv mice. Exp. Hematol., 18:243-247, 1990.

33. Fujita, J., Onoue, H., Ebi, Y., Nakayama, H., and Kanakura, Y. In vitro duplication and in vivo cure of mast-cell deficiency of Sl/Sld mutant mice by cloned 3T3 fibroblasts. Proc. Natl. Acad. Sci., U.S.A., 86:2888-2891, 1989.

32. Kuriu, A., Sonoda, S., Kanakura, Y., Jozaki, K., Yamatodani, A., and Kitamura, Y. Proliferative potential of degranulated murine peritoneal mast cells. Blood, 74:925-929, 1989.

31. Kuriu, A., Fujita, J., Kanakura, Y., Yonezawa, T., Yoshida, K., and Kitamura, Y. Acceleration of a murine T-cell leukemia associated with loss of interleukin-3 producing activity. Leukemia Res., 13:77-82, 1989.

30. Kitamura, Y., Kanakura, Y., Kuriu, A., Fujita, J., and Nakano, T. Unique features in differentiation of mast cells. In Cell Differentiation, Genes and Cancer (eds, Kakunaga, T., Sugimura, T., Tomatis, L., and Yamazaki, H.), IARC, Lyon, pp 11-19, 1988.

29. Nakano, T., Waki, N., Kanakura, Y., Fujita, J., Sonoda, S., Asai, H., and Kitamura, Y. Hybrid resistance to parental bone marrow-derived cultured mast cells in the skin but not in the peritoneal cavity of (WB X C57BL/6)F1-W/Wv mice. Exp. Hematol., 16:908-911, 1988.

28. Kanakura, Y., Thompson, H., Nakano, T., Yamamura, T., Asai, H., Kitamura, Y., Metcalfe, D. D., and Galli, S. J. Multiple bidirectional alterations of phenotype and changes in proliferative potential during the in vitro and in vivo passage of clonal mast cell populations derived from mouse peritoneal mast cells. Blood, 72:877-885, 1988.

27. Fujita, J., Nakayama, H., Onoue, H., Ebi, Y., Kanakura, Y., Kuriu, A., and Kitamura, Y. Failure of W/Wv mouse-derived cultured mast cells to enter S phase upon contact with NIH/3T3 fibroblasts. Blood, 72:463-468, 1988.

26. Kanakura, Y., Kuriu, A., Waki, N., Nakano, T., Asai, H., Yonezawa, T., and Kitamura, Y. Changes in numbers and types of mast cell colony-forming cells in the peritoneal cavity of mice after injection of distilled water: evidence that mast cells suppress differentiation of bone marrow-derived precursors. Blood, 71:573-580, 1988.

25. Tominaga, N., Katagiri, S., Hamaguchi, Y., Nishiura, T., Kanakura, Y., Kanayama, Y., Nagao, K., Kakiuchi, Y., Nishida, K., Abe, T., Honjo, T., Yonezawa, T., and Tarui, S. Plasma cell leukemia of non-producer type with missing light chain gene rearrangement. Br. J. Haematol., 73:213-218, 1988.

24. Fujita, J., Nakayama, H., Onoue, H., Kanakura, Y., Nakano, T., Asai, H., Takeda, S., Honjo, T., and Kitamura, Y. Fibroblast dependent growth of mouse mast cells in vitro: duplication of mast cell depletion in mutant mice of W/Wv genotype. J. Cell. Physiol., 134:78-84, 1988.

23. Tomiyama, Y., Kurata, Y., Mizutani, H., Kanakura, Y., Tsubakio, T., Yonezawa, T., and Tarui, S. Platelet glycoprotein IIb as a target antigen in two patients with chronic thrombocytopenic purpura. Br. J. Haematol., 66:535-538, 1987.

22. Fujita, K., Ohuchi, N., Yao, T., Okumura, M., Fukushima, Y., Kanakura, Y., Kitamura, Y., and Fujita, J. Frequent overexpression, but not activation by point mutation, of ras genes in primary human gastric cancers. Gastroenterology, 93: 1339-1345, 1987.

21. Kitamura, Y., Kanakura, Y., Fujita, J., and Nakano, T. Differentiation and transdifferentiation of mast cells; a unique member of the hematopoietic cell family. Int. J. Cell Clon., 5:108-121, 1987.

20. Kanakura, Y., Sonoda, S., Nakano, T., Fujita, J., Kuriu, A., Asai, H., and Kitamura, Y. Formation of mast cell colonies in methylcellulose by mouse skin cells and development of mucosal-like mast cells from the cloned cells in the gastric mucosa of W/Wv mice. Am. J. Pathol., 129:168-176,1987.

19. Kitamura, Y., Kanakura, Y., Sonoda, S., Asai, H., and Nakano, T. Mutual phenotypic change between connective tissue type and mucosal mast cells. Int. Arch. Allergy Appl. Immunol., 82:244-248, 1987.

18. Otsu, K., Nakano, T., Kanakura, Y., Asai, H., Katz, H. R., Austen, K. F., Stevens,R. L., Galli, S. J., and Kitamura, Y. Phenotypic changes of bone marrow-derived mast cells after intraperitoneal transfer into W/Wv mice that are genetically deficient in mast cells. J. Exp. Med., 165:615-627, 1987.

17. Nakano, T., Kanakura, Y., Nakahata, T., Matsuda, H., and Kitamura, Y. Genetically mast-cell deficient W/Wv mice as a tool for investigations about differentiation and function of mast cells. Fed. Proc., 46:1920-1923, 1987.

16. Nakano, T., Kanakura, Y., Asai, H., and Kitamura, Y. Changing processes from bone marrow-derived cultured mast cells to connective tissue-type mast cells in the peritoneal cavity of mast cell-deficient W/Wv mice: Association of proliferation arrest and differentiation. J. Immunol., 138:544-549, 1987.

15. Hamaguchi, Y., Kanakura, Y., Fujita, J., Takeda, S., Nakano, T., Tarui, S., Honjo, T., and Kitamura, Y. Interleukin 4 as an essential factor for in vitro clonal growth of murine connective tissue type mast cells. J. Exp. Med., 165:268-273, 1987.

14. Kanakura, Y., Yonezawa, T., Hamaguchi, Y., Otsuka, A., Matayoshi, Y., Kondo, H., Tamaki, T., Katagiri, S., Kanayama, Y., Nishiura, T., Aozasa, K., and Tarui, S. Acute promyelocytic leukemia with an intracerebral mass and meningial involvement following treatment of non-Hodgkin's lymphoma. Cancer, 59:94-98, 1987.

13. Sonoda, S., Nakano, T., Kanakura, Y., Sonoda, T., Asai, H., and Kitamura, Y. Hybrid resistance to parental mast cell precursors in the skin of (WB X C57BL/6)F1-W/Wv mice. J. Immunol., 137:2152-2155, 1986.

12. Kitamura, Y., Nakano, T., and Kanakura, Y. Transdifferentiation between mast cell subpopulations. Dev. Growth Differ., 28:321-325, 1986.

11. Sonoda, S., Sonoda, T., Nakano, T., Kanayama, Y., Kanakura, Y., Asai, H., Yonezawa, T., and Kitamura, Y. Development of mucosal mast cells after injection of a single connective tissue-type mast cell in the stomach mucosa of genetically mast-cell deficient W/Wv mice. J. Immunol., 137:1319-1322, 1986.

10. Kitamura, Y., Nakano, T., Kanakura, Y., and Matsuda, H. Factors influencing mast cell differentiation. In Proc. XII Int. Congress Allergy Clin. Immunol. (ed., Leid, C. E., Mosby Co., St. Louis, pp154-158, 1986.

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1. Tsubakio, T., Kurata, Y., Katagiri, S., Kanakura, Y., Tamaki, T., Kuyama, J., Kanayama, Y., Yonezawa, T., and Tarui, S. Alteration of T cell subsets and immunoglobulin synthesis in vitro during high dose g-globulin therapy in patients with idiopathic thrombocytopenic purpura. Clin. Exp. Immunol., 53:697-702,1983.